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EB3 Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth. May be involved in spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration. Belongs to the MAPRE family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding
Chromosomal Location of Human Ortholog: 2p23.3
Cellular Component: cytoplasm; midbody
Molecular Function: identical protein binding; microtubule binding; protein binding
Biological Process: cell cycle; cell division; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of transcription, DNA-templated
Reference #:  Q9UPY8 (UniProtKB)
Alt. Names/Synonyms: APC binding protein; EB1 protein family member 3; EB3; EBF3; EBF3-S; End-binding protein 3; MAPRE3; MARE3; Microtubule-associated protein RP/EB family member 3; microtubule-associated protein, RP/EB family, member 3; RP3
Gene Symbols: MAPRE3
Molecular weight: 31,982 Da
Basal Isoelectric point: 5.33  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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