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TrkC a receptor tyrosine kinase of the TRK family. Receptor for neurotrophin-3 (NT-3). Known substrates for the trk receptors are SHC, PI-3 kinase, and PLCG1. Four alternatively spliced isoforms are known. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; Trk family
Chromosomal Location of Human Ortholog: 15q25.3
Cellular Component: cytoplasm; integral component of plasma membrane; plasma membrane; receptor complex
Molecular Function: ATP binding; GPI-linked ephrin receptor activity; neurotrophin binding; neurotrophin receptor activity; p53 binding; protein binding
Biological Process: activation of MAPK activity; activation of protein kinase B activity; cellular response to retinoic acid; circadian rhythm; cochlea development; ephrin receptor signaling pathway; heart development; lens fiber cell differentiation; mechanoreceptor differentiation; modification by virus of host cell transcription; negative regulation of astrocyte differentiation; negative regulation of protein phosphorylation; neuron fate specification; neuron migration; neurotrophin signaling pathway; peptidyl-tyrosine phosphorylation; positive regulation of actin cytoskeleton reorganization; positive regulation of apoptosis; positive regulation of axon extension involved in regeneration; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of gene expression; positive regulation of peptidyl-serine phosphorylation; positive regulation of positive chemotaxis; positive regulation of protein phosphorylation; positive regulation of synaptogenesis; protein autophosphorylation; response to axon injury; response to corticosterone stimulus; response to ethanol; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  Q16288 (UniProtKB)
Alt. Names/Synonyms: ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; ETV6-NTRK3 fusion partner; gp145(trkC); GP145-TrkC; Neurotrophic tyrosine kinase receptor type 3; neurotrophic tyrosine kinase, receptor, type 3; neurotrophin 3 receptor; NT-3 growth factor receptor; NTRK3; Trk-C; TRKC; TrkC tyrosine kinase; tyrosine kinase receptor C
Gene Symbols: NTRK3
Molecular weight: 94,428 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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