Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
PhosphoSitePlus
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:
TrkB

Overview
TrkB a receptor tyrosine kinase of the Trk family. Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3, -4 and -5 but not nerve growth factor (NGF). Involved in the development and maintenance of the nervous system. Three splice variant isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; Trk family
Chromosomal Location of Human Ortholog: 13 B1|13 31.2 cM
Cellular Component: axon; axon terminus; cell soma; cell surface; cytoplasm; cytosol; dendrite; dendritic spine; early endosome; endosome; excitatory synapse; growth cone; integral component of membrane; integral component of plasma membrane; membrane; perikaryon; plasma membrane; postsynaptic density; postsynaptic membrane; presynaptic active zone; receptor complex; rough endoplasmic reticulum; terminal bouton
Molecular Function: ATP binding; brain-derived neurotrophic factor binding; brain-derived neurotrophic factor-activated receptor activity; kinase activity; neurotrophin binding; neurotrophin receptor activity; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein tyrosine kinase activity; receptor tyrosine kinase binding; transferase activity; transmembrane receptor protein tyrosine kinase activity
Biological Process: brain-derived neurotrophic factor receptor signaling pathway; cell differentiation; central nervous system neuron development; cerebral cortex development; circadian rhythm; feeding behavior; glutamate secretion; learning; long-term memory; mechanoreceptor differentiation; multicellular organism development; negative regulation of anoikis; negative regulation of neuron apoptosis; nervous system development; neuromuscular junction development; neuron differentiation; neuron migration; oligodendrocyte differentiation; peripheral nervous system neuron development; phosphorylation; positive regulation of axonogenesis; positive regulation of cell proliferation; positive regulation of gene expression; positive regulation of glucocorticoid receptor signaling pathway; positive regulation of MAPK cascade; positive regulation of neuron projection development; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of synaptic transmission, glutamatergic; positive regulation of synaptogenesis; protein amino acid phosphorylation; protein autophosphorylation; regulation of dendrite development; regulation of GTPase activity; regulation of MAPK cascade; regulation of metabolic process; regulation of neurotransmitter secretion; regulation of protein kinase B signaling; retina development in camera-type eye; retinal rod cell development; transmembrane receptor protein tyrosine kinase signaling pathway; vasculogenesis
Reference #:  P15209 (UniProtKB)
Alt. Names/Synonyms: AI848316; BDNF/NT-3 growth factors receptor; C030027L06Rik; GP145-TrkB/GP95-TrkB; Neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine kinase, receptor, type 2; Ntrk2; Tkrb; Trk-B; Trkb; TrkB tyrosine kinase
Gene Symbols: Ntrk2
Molecular weight: 92,133 Da
Basal Isoelectric point: 6.08  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below

TrkB

Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

Substrate Sequence Logo
Sequence Logo

STRING  |  Reactome  |  BioGPS  |  Scansite  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene