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SUCLG1 Catalyzes the ATP- or GTP-dependent ligation of succinate and CoA to form succinyl-CoA. The nature of the beta subunit determines the nucleotide specificity. Heterodimer of an alpha and a beta subunit. Belongs to the succinate/malate CoA ligase alpha subunit family. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - propanoate; EC; EC; Ligase; Mitochondrial
Chromosomal Location of Human Ortholog: 2p11.2
Cellular Component: cytosol; mitochondrial inner membrane; mitochondrial matrix; mitochondrion; plasma membrane
Molecular Function: cofactor binding; nucleotide binding; RNA binding; succinate-CoA ligase (ADP-forming) activity; succinate-CoA ligase (GDP-forming) activity
Biological Process: tricarboxylic acid cycle
Disease: Mitochondrial Dna Depletion Syndrome 9 (encephalomyopathic Type With Methylmalonic Aciduria)
Reference #:  P53597 (UniProtKB)
Alt. Names/Synonyms: FLJ21114; FLJ43513; GALPHA; SCS-alpha; SUCA; succinate-CoA ligase, alpha subunit; Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase subunit alpha; SUCLA1; SUCLG1
Gene Symbols: SUCLG1
Molecular weight: 36,250 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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