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ARHGAP25 GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: GAP; GAP, Rac/Rho
Chromosomal Location of Human Ortholog: 2p13.3
Cellular Component: cytosol; phagocytic cup
Molecular Function: GTPase activator activity
Biological Process: actin filament organization; negative regulation of small GTPase mediated signal transduction; phagocytosis, engulfment; positive regulation of GTPase activity; regulation of small GTPase mediated signal transduction; signal transduction
Reference #:  P42331 (UniProtKB)
Alt. Names/Synonyms: ARHGAP25; KAIA0053; KIAA0053; RHG25; Rho GTPase activating protein 25; Rho GTPase-activating protein 25; Rho-type GTPase-activating protein 25
Gene Symbols: ARHGAP25
Molecular weight: 73,435 Da
Basal Isoelectric point: 6.04  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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