Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

TIE1 a transmembrane tyrosine-protein kinase that modulates TEK/TIE2 activity and contribute to the regulation of angiogenesis. An endothelial cell specific ligand-receptor necessary for lymphatic development, angiogenesis, vascular remodelling, permeability and inflammation. Belongs to the protein kinase superfamily. Tyr protein kinase family. Tie subfamily. Three isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB
Protein type: EC; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; Tie family
Chromosomal Location of Human Ortholog: 1p34.2
Cellular Component: integral component of plasma membrane
Molecular Function: ATP binding; protein binding; transmembrane receptor protein tyrosine kinase activity
Biological Process: angiogenesis; in utero embryonic development; mesoderm development; negative regulation of angiogenesis; negative regulation of cell migration; peptidyl-tyrosine phosphorylation; plasma membrane fusion; response to retinoic acid; signal transduction; vasculogenesis
Reference #:  P35590 (UniProtKB)
Alt. Names/Synonyms: JTK14; soluble TIE1 variant 1; soluble TIE1 variant 2; soluble TIE1 variant 3; soluble TIE1 variant 4; soluble TIE1 variant 5; TIE; TIE1; tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1; tyrosine kinase with immunoglobulin-like and EGF-like domains 1; Tyrosine-protein kinase receptor Tie-1
Gene Symbols: TIE1
Molecular weight: 125,090 Da
Basal Isoelectric point: 6.63  Predict pI for various phosphorylation states
CST Pathways:  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene