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Protein Page:
CYP2C8

Overview
CYP2C8 Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti- cancer drug paclitaxel (taxol). Belongs to the cytochrome P450 family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Cofactor and Vitamin Metabolism - retinol; EC 1.14.14.1; Lipid Metabolism - arachidonic acid; Lipid Metabolism - linoleic acid; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450
Chromosomal Location of Human Ortholog: 10q23.33
Cellular Component: endoplasmic reticulum membrane
Molecular Function: arachidonic acid epoxygenase activity; monooxygenase activity; oxygen binding
Biological Process: drug metabolic process; epoxygenase P450 pathway; exogenous drug catabolic process; organic acid metabolic process; steroid metabolic process; xenobiotic metabolic process
Reference #:  P10632 (UniProtKB)
Alt. Names/Synonyms: CP2C8; CPC8; CYP2C8; CYPIIC8; Cytochrome P450 2C8; Cytochrome P450 form 1; Cytochrome P450 IIC2; Cytochrome P450 MP-12; Cytochrome P450 MP-20; cytochrome P450, family 2, subfamily C, polypeptide 8; cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8; flavoprotein-linked monooxygenase; microsomal monooxygenase; MP-12/MP-20; P450 form 1; S-mephenytoin 4-hydroxylase
Gene Symbols: CYP2C8
Molecular weight: 55,825 Da
Basal Isoelectric point: 8.8  Predict pI for various phosphorylation states
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CYP2C8

Protein Structure Not Found.
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