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STRC Essential to the formation of horizontal top connectors between outer hair cell stereocilia. Defects in STRC are the cause of deafness autosomal recessive type 16 (DFNB16). DFNB16 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. Defects in STRC are a cause of deafness-infertility syndrome (DIS). DIS is characterized by deafness and infertility and is caused by large contiguous gene deletions at 15q15.3 that removes both STRC and CATSPER2 genes. Belongs to the stereocilin family. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 15q15.3
Cellular Component: cell surface; stereocilium bundle tip
Biological Process: auditory receptor cell stereocilium organization and biogenesis; cell-matrix adhesion; sensory perception of sound
Disease: Deafness, Autosomal Recessive 16; Deafness, Sensorineural, And Male Infertility; Spermatogenic Failure 7
Reference #:  Q7RTU9 (UniProtKB)
Alt. Names/Synonyms: DFNB16; MGC156147; Stereocilin; STRC
Gene Symbols: STRC
Molecular weight: 192,967 Da
Basal Isoelectric point: 5.27  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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