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PSPH Catalyzes the last step in the biosynthesis of serine from carbohydrates. The reaction mechanism proceeds via the formation of a phosphoryl-enzyme intermediates. Defects in PSPH are the cause of phosphoserine phosphatase deficiency (PSPHD)[MIM:614023]. A disorder that results in pre- and postnatal growth retardation, moderate psychomotor retardation and facial features suggestive of Williams syndrome. Belongs to the SerB family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - glycine, serine and threonine; EC; Hydrolase; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 7p11.2
Cellular Component: cytosol; neuron projection
Molecular Function: calcium ion binding; magnesium ion binding; phosphoserine phosphatase activity; protein homodimerization activity
Biological Process: dephosphorylation; L-serine biosynthetic process; L-serine metabolic process; response to mechanical stimulus; response to nutrient levels; response to testosterone stimulus
Disease: Phosphoserine Phosphatase Deficiency
Reference #:  P78330 (UniProtKB)
Alt. Names/Synonyms: L-3-phosphoserine phosphatase; O-phosphoserine phosphohydrolase; Phosphoserine phosphatase; PSP; PSPase; PSPH; SERB
Gene Symbols: PSPH
Molecular weight: 25,008 Da
Basal Isoelectric point: 5.53  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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