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FGG Fibrinogen has a double function: yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation. Defects in FGG are a cause of congenital afibrinogenemia (CAFBN). This rare autosomal recessive disorder is characterized by bleeding that varies from mild to severe and by complete absence or extremely low levels of plasma and platelet fibrinogen. Patients with congenital fibrinogen abnormalities can manifest different clinical pictures. Some cases are clinically silent, some show a tendency toward bleeding and some show a predisposition for thrombosis with or without bleeding. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q32.1
Cellular Component: cell surface; endoplasmic reticulum lumen; external side of plasma membrane; extracellular region; extracellular space; fibrinogen complex; plasma membrane
Molecular Function: cell adhesion molecule binding; metal ion binding; protein binding; protein binding, bridging; protein homodimerization activity; receptor binding; structural molecule activity
Biological Process: blood coagulation; cell-matrix adhesion; cellular protein complex assembly; cellular protein metabolic process; extracellular matrix organization; fibrinolysis; plasminogen activation; platelet degranulation; positive regulation of exocytosis; positive regulation of heterotypic cell-cell adhesion; positive regulation of protein secretion; positive regulation of vasoconstriction; post-translational protein modification; protein polymerization; protein secretion; response to calcium ion; toll-like receptor signaling pathway
Disease: Afibrinogenemia, Congenital; Dysfibrinogenemia, Congenital
Reference #:  P02679 (UniProtKB)
Alt. Names/Synonyms: FGG; FIBG; Fibrinogen gamma chain; fibrinogen, gamma chain; fibrinogen, gamma polypeptide
Gene Symbols: FGG
Molecular weight: 51,512 Da
Basal Isoelectric point: 5.37  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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