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USP2 Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Homooligomer. Found in trimeric complex with MDM2 and MDM4 and UPB2. Interacts with CCND1; the interaction is direct and promotes its stabilization by antagonizing ubiquitin-dependent degradation. Interacts (via N-terminus and C- terminus) with MDM2. Interacts with MDM4. Down-regulated by cisplatin. Expressed in mesangial cells of the kidney and in different types of glomerulonephritides. Cleavage is inhibited by ubiquitin in a dosage- dependent manner. Cleavage is blocked by ubiquitin aldehyde. Belongs to the peptidase C19 family. USP2 subfamily. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Protease; Ubiquitin-specific protease
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: nucleoplasm
Molecular Function: cyclin binding; cysteine-type endopeptidase activity; protein binding; ubiquitin protein ligase binding; ubiquitin-specific protease activity
Biological Process: circadian behavior; circadian regulation of gene expression; entrainment of circadian clock by photoperiod; locomotor rhythm; negative regulation of transcription from RNA polymerase II promoter; positive regulation of mitotic cell cycle; protein deubiquitination; protein stabilization
Reference #:  O75604 (UniProtKB)
Alt. Names/Synonyms: 41 kDa ubiquitin-specific protease; Deubiquitinating enzyme 2; Ubiquitin carboxyl-terminal hydrolase 2; ubiquitin specific peptidase 2; ubiquitin specific protease 12; ubiquitin specific protease 2; ubiquitin specific protease 9; Ubiquitin thioesterase 2; Ubiquitin-specific-processing protease 2; UBP2; UBP41; USP2; USP9
Gene Symbols: USP2
Molecular weight: 68,072 Da
Basal Isoelectric point: 9.15  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.
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