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MAOA Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine. Defects in MAOA are the cause of Brunner syndrome (BRUNS). Brunner syndrome is a form of X-linked non- dysmorphic mild mental retardation. Male patients are affected by a syndrome of borderline mental retardation and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior. Belongs to the flavin monoamine oxidase family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - arginine and proline; Amino Acid Metabolism - glycine, serine and threonine; Amino Acid Metabolism - histidine; Amino Acid Metabolism - phenylalanine; Amino Acid Metabolism - tryptophan; Amino Acid Metabolism - tyrosine; EC; Membrane protein, integral; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450
Chromosomal Location of Human Ortholog: Xp11.3
Cellular Component: integral component of membrane; mitochondrial outer membrane; mitochondrion
Molecular Function: amine oxidase activity
Biological Process: biogenic amine metabolic process; dopamine catabolic process; neurotransmitter catabolic process; neurotransmitter metabolic process
Disease: Brunner Syndrome
Reference #:  P21397 (UniProtKB)
Alt. Names/Synonyms: Amine oxidase [flavin-containing] A; AOFA; MAO-A; MAOA; monoamine oxidase A; Monoamine oxidase type A
Gene Symbols: MAOA
Molecular weight: 59,682 Da
Basal Isoelectric point: 7.94  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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