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Protein Page:
MED11

Overview
MED11 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Belongs to the Mediator complex subunit 11 family. Note: This description may include information from UniProtKB.
Protein type: Transcription initiation complex
Chromosomal Location of Human Ortholog: 17p13.2
Cellular Component: Srb-mediator complex; ubiquitin ligase complex
Molecular Function: protein binding
Biological Process: protein ubiquitination; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent
Reference #:  Q9P086 (UniProtKB)
Alt. Names/Synonyms: HSPC296; MED11; mediator complex subunit 11; mediator of RNA polymerase II transcription, subunit 11; MGC88387
Gene Symbols: MED11
Molecular weight: 13,129 Da
Basal Isoelectric point: 5.71  Predict pI for various phosphorylation states
Select Structure to View Below

MED11

Protein Structure Not Found.

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