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Protein Page:

FOXA3 Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 19q13.32
Cellular Component: actin cytoskeleton; nucleoplasm; nucleus
Molecular Function: DNA binding transcription factor activity; protein domain specific binding; sequence-specific DNA binding; transcription factor binding
Biological Process: anatomical structure morphogenesis; cell differentiation; cell glucose homeostasis; cellular response to starvation; covalent chromatin modification; multicellular organism development; positive regulation of transcription from RNA polymerase II promoter; spermatogenesis; transcription, DNA-dependent
Reference #:  P55318 (UniProtKB)
Alt. Names/Synonyms: FKHH3; Fork head-related protein FKH H3; forkhead box A3; Forkhead box protein A3; FOXA3; hepatocyte nuclear factor 3, gamma; Hepatocyte nuclear factor 3-gamma; HNF-3-gamma; HNF-3G; HNF3G; MGC10179; TCF-3G; TCF3G; Transcription factor 3G
Gene Symbols: FOXA3
Molecular weight: 37,140 Da
Basal Isoelectric point: 7.01  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling
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Protein Structure Not Found.
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