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SLPI Acid-stable proteinase inhibitor with strong affinities for trypsin, chymotrypsin, elastase, and cathepsin G. May prevent elastase-mediated damage to oral and possibly other mucosal tissues. Note: This description may include information from UniProtKB.
Protein type: Inhibitor; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 20q13.12
Cellular Component: extracellular matrix; extracellular region; extracellular space; Golgi apparatus
Molecular Function: DNA binding; endopeptidase inhibitor activity; enzyme binding; mRNA binding; protein binding; serine-type endopeptidase inhibitor activity
Biological Process: antibacterial humoral response; immune response; innate immune response; negative regulation of protein binding; negative regulation of viral genome replication; neutrophil degranulation; response to lipopolysaccharide
Reference #:  P03973 (UniProtKB)
Alt. Names/Synonyms: ALK1; ALP; antileukoproteinase; BLPI; HUSI; HUSI-I; MPI; mucus proteinase inhibitor; OTTHUMP00000031775; P03973; secretory leukocyte peptidase inhibitor; secretory leukocyte protease inhibitor (antileukoproteinase); seminal proteinase inhibitor; SLPI; WAP four-disulfide core domain 4; WAP4; WFDC4
Gene Symbols: SLPI
Molecular weight: 14,326 Da
Basal Isoelectric point: 9.11  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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