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SILV Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity. Belongs to the PMEL/NMB family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Vesicle
Chromosomal Location of Human Ortholog: 12q13.2
Cellular Component: endoplasmic reticulum membrane; extracellular region; Golgi apparatus; integral component of plasma membrane; melanosome; plasma membrane
Molecular Function: protein binding
Biological Process: melanin biosynthetic process; melanosome organization; pigmentation during development
Reference #:  P40967 (UniProtKB)
Alt. Names/Synonyms: 95 kDa melanocyte-specific secreted glycoprotein; D12S53E; gp100; M-alpha; M-beta; ME20; ME20-M; ME20-S; ME20M; ME20S; Melanocyte protein mel 17; Melanocyte protein Pmel 17; Melanocytes lineage-specific antigen GP100; Melanoma-associated ME20 antigen; melanosomal matrix protein17; P1; P100; P26; PME17; PMEL; Pmel 17; PMEL17; Secreted melanoma-associated ME20 antigen; SI; SIL; SILV; silver (mouse homolog)-like; silver homolog (mouse); Silver locus protein homolog; Silver, mouse, homolog of
Gene Symbols: PMEL
Molecular weight: 70,255 Da
Basal Isoelectric point: 5.37  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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