a tyrosine kinase that binds Cdc42 in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. May be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42 and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Amplification in primary tumors correlates with metastatic potential . Two differentially spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Ack family; EC 188.8.131.52; EC 184.108.40.206; Kinase, protein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); TK group