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CXCL10 Chemotactic for monocytes and T-lymphocytes. Binds to CXCR3. Belongs to the intercrine alpha (chemokine CxC) family. Note: This description may include information from UniProtKB.
Protein type: Chemokine; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q21.1
Cellular Component: extracellular region; extracellular space
Molecular Function: cAMP-dependent protein kinase regulator activity; chemokine activity; CXCR3 chemokine receptor binding; heparin binding; protein binding; receptor binding
Biological Process: blood circulation; cell surface receptor linked signal transduction; cell-cell signaling; chemotaxis; endothelial cell activation; G-protein coupled receptor protein signaling pathway; immune response; inflammatory response; muscle development; positive regulation of cAMP metabolic process; positive regulation of release of sequestered calcium ion into cytosol; positive regulation of transcription from RNA polymerase II promoter; regulation of cell proliferation; signal transduction
Reference #:  P02778 (UniProtKB)
Alt. Names/Synonyms: 10 kDa interferon gamma-induced protein; C-X-C motif chemokine 10; C7; chemokine (C-X-C motif) ligand 10; crg-2; CXCL10; CXCL10(1-73); CXL10; gamma IP10; Gamma-IP10; gIP-10; IFI10; INP10; interferon-inducible cytokine IP-10; IP-10; mob-1; protein 10 from interferon (gamma)-induced cell line; SCYB10; small inducible cytokine subfamily B (Cys-X-Cys), member 10; Small-inducible cytokine B10
Gene Symbols: CXCL10
Molecular weight: 10,881 Da
Basal Isoelectric point: 9.93  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.
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