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IL6 Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. Genetic variations in IL6 are associated with susceptibility to rheumatoid arthritis systemic juvenile (RASJ). An inflammatory articular disorder with systemic- onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis. A IL6 promoter polymorphism is associated with a lifetime risk of development of Kaposi sarcoma in HIV-infected men. Belongs to the IL-6 superfamily. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 7p15.3
Cellular Component: endoplasmic reticulum lumen; external side of plasma membrane; extracellular region; extracellular space; interleukin-6 receptor complex
Molecular Function: cytokine activity; growth factor activity; interleukin-6 receptor binding; protein binding
Biological Process: acute-phase response; aging; bone remodeling; cell growth; cell redox homeostasis; cellular protein metabolic process; cellular response to nutrient levels; cytokine-mediated signaling pathway; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; defense response to protozoan; defense response to virus; endocrine pancreas development; glucose homeostasis; hepatic immune response; humoral immune response; inflammatory response; lymphocyte costimulation; monocyte chemotaxis; muscle maintenance; negative regulation of apoptosis; negative regulation of bone resorption; negative regulation of cell proliferation; negative regulation of chemokine biosynthetic process; negative regulation of collagen biosynthetic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of cytokine secretion; negative regulation of fat cell differentiation; negative regulation of gluconeogenesis; negative regulation of hormone secretion; negative regulation of membrane potential; negative regulation of muscle organ development; negative regulation of protein kinase activity; neuron projection development; neutrophil apoptosis; neutrophil mediated immunity; platelet activation; positive regulation of acute inflammatory response; positive regulation of apoptosis; positive regulation of B cell activation; positive regulation of cell proliferation; positive regulation of chemokine production; positive regulation of DNA replication; positive regulation of epithelial cell proliferation; positive regulation of immunoglobulin secretion; positive regulation of interleukin-6 production; positive regulation of JAK-STAT cascade; positive regulation of leukocyte chemotaxis; positive regulation of MAPK cascade; positive regulation of NF-kappaB transcription factor activity; positive regulation of nitric oxide biosynthetic process; positive regulation of osteoblast differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein import into nucleus, translocation; positive regulation of protein kinase B signaling; positive regulation of smooth muscle cell proliferation; positive regulation of T cell proliferation; positive regulation of T-helper 2 cell differentiation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; positive regulation of translation; positive regulation of transmission of nerve impulse; positive regulation of tyrosine phosphorylation of STAT protein; post-translational protein modification; regulation of angiogenesis; regulation of cell shape; regulation of circadian sleep/wake cycle, non-REM sleep; response to amino acid; response to antibiotic; response to caffeine; response to calcium ion; response to cold; response to drug; response to electrical stimulus; response to glucocorticoid stimulus; response to heat; response to insulin stimulus; response to peptidoglycan; response to yeast
Disease: Arteriovenous Malformations Of The Brain; Inflammatory Bowel Disease 1; Kaposi Sarcoma, Susceptibility To; Rheumatoid Arthritis, Systemic Juvenile
Reference #:  P05231 (UniProtKB)
Alt. Names/Synonyms: B cell stimulatory factor-2; B-cell differentiation factor; B-cell stimulatory factor 2; BSF-2; BSF2; CDF; CTL differentiation factor; HGF; HSF; Hybridoma growth factor; IFN-beta-2; IFNB2; IL-6; IL6; Interferon beta-2; interleukin 6 (interferon, beta 2); interleukin BSF-2; Interleukin-6
Gene Symbols: IL6
Molecular weight: 23,718 Da
Basal Isoelectric point: 6.17  Predict pI for various phosphorylation states
CST Pathways:  IL6 Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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