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PREB Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription. Guanine nucleotide exchange factor that activates SARA2. Required for the formation of COPII transport vesicles from the ER. Note: This description may include information from UniProtKB.
Protein type: GEF, misc.; Membrane protein, integral; Transcription factor
Chromosomal Location of Human Ortholog: 2p23.3
Cellular Component: endoplasmic reticulum membrane; Golgi membrane; integral component of endoplasmic reticulum membrane; membrane; nucleus
Molecular Function: DNA binding; GTPase activator activity; GTPase binding; guanyl-nucleotide exchange factor activity; protein binding; Sar guanyl-nucleotide exchange factor activity
Biological Process: COPII vesicle coating; ER to Golgi vesicle-mediated transport; positive regulation of GTPase activity; protein exit from endoplasmic reticulum; protein secretion; regulation of transcription, DNA-templated; transcription, DNA-dependent
Reference #:  Q9HCU5 (UniProtKB)
Alt. Names/Synonyms: Mammalian guanine nucleotide exchange factor mSec12; MGC3467; PREB; prolactin regulatory binding-element protein; prolactin regulatory element binding; Prolactin regulatory element-binding protein; SEC12
Gene Symbols: PREB
Molecular weight: 45,468 Da
Basal Isoelectric point: 8.02  Predict pI for various phosphorylation states
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