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IGF2 The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development. Epigenetic changes of DNA hypomethylation in IGF2 are a cause of Silver-Russell syndrome (SRS). A clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations. The phenotypic expression changes during childhood and adolescence, with the facial features and asymmetry usually becoming more subtle with age. Belongs to the insulin family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11p15.5
Cellular Component: extracellular region; plasma membrane
Molecular Function: growth factor activity; hormone activity; insulin receptor binding; insulin-like growth factor receptor binding; protein binding; protein serine/threonine kinase activator activity; receptor activator activity
Biological Process: cellular protein metabolic process; embryonic placenta development; genetic imprinting; glucose metabolic process; in utero embryonic development; insulin receptor signaling pathway; multicellular organism development; negative regulation of transcription from RNA polymerase II promoter; ossification; platelet degranulation; positive regulation of activated T cell proliferation; positive regulation of catalytic activity; positive regulation of cell division; positive regulation of cell proliferation; positive regulation of glycogen biosynthetic process; positive regulation of insulin receptor signaling pathway; positive regulation of MAPK cascade; positive regulation of mitotic nuclear division; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein kinase B signaling; positive regulation of protein phosphorylation; regulation of histone modification; regulation of muscle cell differentiation; regulation of transcription, DNA-templated; skeletal system development
Disease: Beckwith-wiedemann Syndrome; Growth Restriction, Severe, With Distinctive Facies; Silver-russell Syndrome; Wilms Tumor 1
Reference #:  P01344 (UniProtKB)
Alt. Names/Synonyms: C11orf43; FLJ22066; FLJ44734; IGF-II; IGF2; INSIGF; insulin-like growth factor 2; insulin-like growth factor 2 (somatomedin A); Insulin-like growth factor II; Insulin-like growth factor II Ala-25 Del; insulin-like growth factor type 2; pp9974; Preptin; putative insulin-like growth factor II associated protein; somatomedin A; Somatomedin-A
Gene Symbols: IGF2
Molecular weight: 20,140 Da
Basal Isoelectric point: 9.5  Predict pI for various phosphorylation states
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