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RIPK2 a tyrosine kinase-like kinase of the RIPK family. Activates pro-caspase-1 and pro-caspase-8. Potentiates casp-8-mediated apoptosis. May activate NF-kappaB. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Protein kinase, TKL; RIPK family; TKL group
Chromosomal Location of Human Ortholog: 4 A2|4 6.7 cM
Cellular Component: cytoplasm; cytoskeleton; cytosol; protein complex; vesicle
Molecular Function: CARD domain binding; identical protein binding; LIM domain binding; protein homodimerization activity; protein serine/threonine kinase activity; receptor binding; signal transducer activity
Biological Process: activation of NF-kappaB transcription factor; adaptive immune response; defense response to Gram-positive bacterium; I-kappaB kinase/NF-kappaB cascade; inflammatory response; innate immune response; lipopolysaccharide-mediated signaling pathway; positive regulation of alpha-beta T cell proliferation; positive regulation of apoptosis; positive regulation of chemokine production; positive regulation of cytokine and chemokine mediated signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of immature T cell proliferation; positive regulation of interferon-gamma production; positive regulation of interleukin-1 beta secretion; positive regulation of interleukin-2 production; positive regulation of interleukin-6 production; positive regulation of JNK cascade; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of protein binding; positive regulation of protein ubiquitination; positive regulation of stress-activated MAPK cascade; positive regulation of T-helper 1 cell differentiation; positive regulation of T-helper 1 type immune response; positive regulation of tumor necrosis factor production; regulation of caspase activity; response to exogenous dsRNA; T cell proliferation; T cell receptor signaling pathway; toll-like receptor 2 signaling pathway; toll-like receptor 4 signaling pathway
Reference #:  P58801 (UniProtKB)
Alt. Names/Synonyms: 2210420D18Rik; CARD3; CARDIAK; CCK; D4Bwg0615e; OTTMUSP00000004983; receptor (TNFRSF)-interacting serine-threonine kinase 2; Receptor-interacting serine/threonine-protein kinase 2; RICK; RIP2; Ripk2
Gene Symbols: Ripk2
Molecular weight: 60,400 Da
Basal Isoelectric point: 6.73  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  NF-kB Signaling  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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