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TCL1A Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity. Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation. Belongs to the TCL1 family. Note: This description may include information from UniProtKB.
Protein type: Oncoprotein; Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 14q32.13
Cellular Component: endoplasmic reticulum; nucleus; protein complex
Molecular Function: identical protein binding; protein binding; protein kinase binding; protein serine/threonine kinase activator activity
Biological Process: multicellular organism development; negative regulation of apoptosis; positive regulation of cell proliferation; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein oligomerization
Reference #:  P56279 (UniProtKB)
Alt. Names/Synonyms: Oncogene TCL-1; Oncogene TCL1; Protein p14 TCL1; T-cell leukemia/lymphoma 1A; T-cell leukemia/lymphoma protein 1A; T-cell lymphoma-1; T-cell lymphoma-1A; TCL1; TCL1A
Gene Symbols: TCL1A
Molecular weight: 13,460 Da
Basal Isoelectric point: 4.98  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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