Enhances the phosphorylation and activation of AKT1, AKT2 and AKT3. Promotes nuclear translocation of AKT1. Enhances cell proliferation, stabilizes mitochondrial membrane potential and promotes cell survival. Homodimer. Interacts with AKT1, AKT2 and AKT3 (via PH domain). Interacts with PNPT1; the interaction has no effect on PNPT1 exonuclease activity. Restricted in the T-cell lineage to immature thymocytes and activated peripheral lymphocytes. Preferentially expressed early in T- and B-lymphocyte differentiation. Belongs to the TCL1 family. Note: This description may include information from UniProtKB.
Protein type: Oncoprotein; Protein kinase, regulatory subunit
Cellular Component: endoplasmic reticulum; nucleus; protein complex
Molecular Function: identical protein binding; protein binding; protein kinase binding; protein serine/threonine kinase activator activity
Biological Process: multicellular organism development; negative regulation of apoptosis; positive regulation of cell proliferation; positive regulation of peptidyl-serine phosphorylation; positive regulation of protein oligomerization