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SLC25A11 Catalyzes the transport of 2-oxoglutarate across the inner mitochondrial membrane in an electroneutral exchange for malate or other dicarboxylic acids, and plays an important role in several metabolic processes, including the malate-aspartate shuttle, the oxoglutarate/isocitrate shuttle, in gluconeogenesis from lactate, and in nitrogen metabolism. Belongs to the mitochondrial carrier family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 11 B3|11 43.21 cM
Cellular Component: integral to membrane; mitochondrial inner membrane; mitochondrion; nucleus
Molecular Function: oxoglutarate:malate antiporter activity; RNA binding; transporter activity
Biological Process: mitochondrial transport
Reference #:  Q9CR62 (UniProtKB)
Alt. Names/Synonyms: 2310022P18Rik; 2oxoc; M2OM; Mitochondrial 2-oxoglutarate/malate carrier protein; OGCP; OTTMUSP00000006344; Slc25a11; solute carrier family 25 (mitochondrial carrier oxoglutarate carrier), member 11; Solute carrier family 25 member 11
Gene Symbols: Slc25a11
Molecular weight: 34,155 Da
Basal Isoelectric point: 9.95  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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