Converts sphingomyelin to ceramide. Also has phospholipase C activities toward 1,2-diacylglycerolphosphocholine and 1,2-diacylglycerolphosphoglycerol. Isoform 2 and isoform 3 have lost catalytic activity. Monomer. Belongs to the acid sphingomyelinase family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC 188.8.131.52; Lipid Metabolism - sphingolipid; Phosphodiesterase
Molecular Function: hydrolase activity, acting on glycosyl bonds; protein binding; sphingomyelin phosphodiesterase activity; zinc ion binding
Biological Process: ceramide biosynthetic process; glycosphingolipid metabolic process; negative regulation of MAP kinase activity; nervous system development; positive regulation of apoptosis; positive regulation of protein dephosphorylation; response to cocaine; response to drug; signal transduction; sphingomyelin catabolic process; sphingomyelin metabolic process