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Protein Page:
MRPL22

Overview
MRPL22 a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L22 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 4q. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Protein type: Translation
Chromosomal Location of Human Ortholog: 5q33.2
Cellular Component: mitochondrial inner membrane; mitochondrial large ribosomal subunit; mitochondrion
Molecular Function: RNA binding; structural constituent of ribosome
Reference #:  Q9NWU5 (UniProtKB)
Alt. Names/Synonyms: 39S ribosomal protein L22, mitochondrial; 39S ribosomal protein L25, mitochondrial; DKFZp781F1071; HSPC158; L22mt; L25mt; mitochondrial ribosomal protein L22; MRP-L22; MRP-L25; MRPL22; MRPL25; RM22; RPML25
Gene Symbols: MRPL22
Molecular weight: 23,641 Da
Basal Isoelectric point: 9.95  Predict pI for various phosphorylation states
Select Structure to View Below

MRPL22

Protein Structure Not Found.
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