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p40phox a component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst. Upon neutrophil stimulation, this protein and other cytosolic elements are sent to the cell membrane from the cytosol to form a complex which produces phagocytic oxygen radicals. Responsible for the downregulation of NADPH-oxidase. Alternative splicing has been observed. Note: This description may include information from UniProtKB.
Protein type: Oxidoreductase
Chromosomal Location of Human Ortholog: 22q12.3
Cellular Component: cytosol; endosome membrane; membrane; NADPH oxidase complex; trans-Golgi network
Molecular Function: ARF guanyl-nucleotide exchange factor activity; phosphatidylinositol 3-phosphate binding; protein binding; protein dimerization activity; superoxide-generating NADPH oxidase activator activity
Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; cell redox homeostasis; immune response; vascular endothelial growth factor receptor signaling pathway; vesicle-mediated transport
Disease: Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-positive, Type Iii
Reference #:  Q15080 (UniProtKB)
Alt. Names/Synonyms: MGC3810; NCF; NCF-4; NCF4; Neutrophil cytosol factor 4; neutrophil cytosolic factor 4; neutrophil cytosolic factor 4, 40kDa; Neutrophil NADPH oxidase factor 4; p40-phox; p40phox; SH3 and PX domain-containing protein 4; SH3PXD4
Gene Symbols: NCF4
Molecular weight: 39,032 Da
Basal Isoelectric point: 6.4  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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