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PDE3B a cGMP-inhibited phosphodiesterase 1 involved in fat metabolism. Inhibition of PDE3B can augment PDE4 inhibitor-induced apoptosis in some patients with chronic lymphocytic leukemia. Note: This description may include information from UniProtKB.
Protein type: EC; Membrane protein, integral; Membrane protein, multi-pass; Nucleotide Metabolism - purine; Phosphodiesterase
Chromosomal Location of Human Ortholog: 7 F1|7 59.46 cM
Cellular Component: endoplasmic reticulum; Golgi apparatus; membrane
Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-nucleotide phosphodiesterase activity; cAMP binding; cGMP-inhibited cyclic-nucleotide phosphodiesterase activity; drug binding; phosphoprotein binding; protein kinase B binding
Biological Process: cAMP catabolic process; cellular response to insulin stimulus; endocrine pancreas development; glucose homeostasis; negative regulation of angiogenesis; negative regulation of cell adhesion; negative regulation of insulin secretion; negative regulation of lipid catabolic process; regulation of insulin secretion
Reference #:  Q61409 (UniProtKB)
Alt. Names/Synonyms: 9830102A01Rik; AI847709; CGI-PDE B; CGIPDE1; cGMP-inhibited 3',5'-cyclic phosphodiesterase B; Cyclic GMP-inhibited phosphodiesterase B; OTTMUSP00000031097; Pde3b; phosphodiesterase 3B, cGMP-inhibited
Gene Symbols: Pde3b
Molecular weight: 122,154 Da
Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states
CST Pathways:  Insulin Receptor Signaling
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Protein Structure Not Found.
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