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NMDAR2D NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family. NR2D/GRIN2D subfamily. Note: This description may include information from UniProtKB.
Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 19q13.33
Cellular Component: plasma membrane
Molecular Function: ionotropic glutamate receptor activity; protein binding; Ras guanyl-nucleotide exchange factor activity
Biological Process: MAPKKK cascade
Disease: Epileptic Encephalopathy, Early Infantile, 46
Reference #:  O15399 (UniProtKB)
Alt. Names/Synonyms: EB11; estrogen receptor binding CpG island; Glutamate [NMDA] receptor subunit epsilon-4; glutamate receptor, ionotropic, N-methyl D-aspartate 2D; GRIN2D; N-methyl D-aspartate receptor subtype 2D; N-methyl-d-aspartate receptor subunit 2D; NMDAR2D; NMDE4; NR2D
Gene Symbols: GRIN2D
Molecular weight: 143,752 Da
Basal Isoelectric point: 8.68  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease  |  Parkinson's Disease
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Protein Structure Not Found.
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