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CPN1 Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation. Defects in CPN1 are the cause of carboxypeptidase N deficiency (CPND). Patients affected present some combination of angioedema or chronic urticaria, as well as hay fever or astma, and have also slightly depressed serum carboxy peptidase N, suggestive of autosomal recessive inheritance of this disorder. Belongs to the peptidase M14 family. Note: This description may include information from UniProtKB.
Protein type: EC; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 10q24.2
Cellular Component: cell soma; extracellular region; extracellular space; Golgi apparatus; secretory granule
Molecular Function: metallocarboxypeptidase activity; serine carboxypeptidase activity; zinc ion binding
Biological Process: insulin processing; regulation of complement activation; response to glucocorticoid stimulus
Disease: Carboxypeptidase N Deficiency
Reference #:  P15169 (UniProtKB)
Alt. Names/Synonyms: ACBP; Anaphylatoxin inactivator; Arginine carboxypeptidase; Carboxypeptidase N catalytic chain; carboxypeptidase N catalytic subunit; Carboxypeptidase N polypeptide 1; carboxypeptidase N polypeptide 1 50 kD; Carboxypeptidase N small subunit; carboxypeptidase N, polypeptide 1; CBPN; CPN; CPN1; FLJ40792; kininase I; Kininase-1; Lysine carboxypeptidase; Plasma carboxypeptidase B; SCPN; Serum carboxypeptidase N
Gene Symbols: CPN1
Molecular weight: 52,286 Da
Basal Isoelectric point: 6.86  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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