Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

MRLC2V myosin regulatory light chain 2, ventricular/cardiac muscle isoform. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in MYL2 are associated with mid-left ventricular chamber type hypertrophic cardiomyopathy. Note: This description may include information from UniProtKB.
Protein type: Contractile
Chromosomal Location of Human Ortholog: 12q24.11
Cellular Component: A band; actin cytoskeleton; cytoskeleton; cytosol; myofibril; myosin complex; sarcomere
Molecular Function: actin monomer binding; calcium ion binding; myosin heavy chain binding; protein binding; structural constituent of muscle
Biological Process: cardiac muscle contraction; cardiac myofibril assembly; heart contraction; heart development; muscle cell fate specification; muscle fiber development; muscle filament sliding; negative regulation of cell growth; positive regulation of the force of heart contraction; post-embryonic development; regulation of striated muscle contraction; regulation of the force of heart contraction; ventricular cardiac muscle tissue morphogenesis
Disease: Cardiomyopathy, Familial Hypertrophic, 10
Reference #:  P10916 (UniProtKB)
Alt. Names/Synonyms: cardiac ventricular myosin light chain 2; CMH10; DKFZp779C0562; MLC-2; MLC-2v; MLC2; MLRV; MYL2; myosin light chain 2; Myosin regulatory light chain 2, ventricular/cardiac muscle isoform; myosin, light chain 2, regulatory, cardiac, slow; myosin, light polypeptide 2, regulatory, cardiac, slow; regulatory light chain of myosin; RLC of myosin; slow cardiac myosin regulatory light chain 2
Gene Symbols: MYL2
Molecular weight: 18,789 Da
Basal Isoelectric point: 4.92  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene