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Nur77 an orphan nuclear receptor and immediate-early gene that regulates cellular proliferation, apoptosis, inflammation, and glucose metabolism. Induced by exercise in muscle and is a functional regulator of glucose metabolism in skeletal muscle. Its level decreases in the muscle of obese insulin-resistant men. Acts concomitantly with NURR1 in regulating the expression of delayed-early genes during liver regeneration. Binds the NGFI-B response element (NBRE) 5'-AAAAGGTCA-3'. May inhibit NF-kappa-B transactivation of IL2. A mediator of TCR-directed thymocyte apoptosis. TCR-signaling induces a FAIM/Akt/Nur77 signaling pathway that is critical for modulating apoptosis in developing thymocytes. A physiological substrate of the MEK-ERK-RSK cascade that modulates nuclear export and intracellular translocation during T cell death. Binds DNA as a monomer. Interacts with GADD45GIP1. Overexpression of Nur77 induces the expression of both p300 and HDAC1. Acetylation by p300 and HDAC1 may regulate the rapid turnover of Nur77 protein. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; DNA-binding; Nuclear receptor
Chromosomal Location of Human Ortholog: 12q13.13
Cellular Component: cytosol; nuclear membrane; nucleoplasm; nucleus
Molecular Function: DNA binding; ligand-dependent nuclear receptor activity; protein binding; protein heterodimerization activity; sequence-specific DNA binding; steroid hormone receptor activity; zinc ion binding
Biological Process: cell migration during sprouting angiogenesis; cellular response to corticotropin-releasing hormone stimulus; cellular response to fibroblast growth factor stimulus; fat cell differentiation; intracellular receptor signaling pathway; negative regulation of cell cycle; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; protein kinase B signaling; signal transduction; steroid hormone mediated signaling; transcription initiation from RNA polymerase II promoter
Reference #:  P22736 (UniProtKB)
Alt. Names/Synonyms: Early response protein NAK1; GFRP1; growth factor-inducible nuclear protein N10; HMR; hormone receptor; MGC9485; N10; NAK-1; NAK1; NGFIB; NP10; NR4A1; Nuclear receptor subfamily 4 group A member 1; nuclear receptor subfamily 4, group A, member 1; Nur77; Orphan nuclear receptor HMR; Orphan nuclear receptor TR3; ST-59; steroid receptor TR3; Testicular receptor 3; TR3; TR3 orphan receptor
Gene Symbols: NR4A1
Molecular weight: 64,463 Da
Basal Isoelectric point: 6.82  Predict pI for various phosphorylation states
CST Pathways:  Growth And Differentiation Control by MAPKs
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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