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SLCO1A2 Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids. Selectively inhibited by the grapefruit juice component naringin. Belongs to the organo anion transporter (TC 2.A.60) family. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 12p12.1
Cellular Component: integral component of plasma membrane; plasma membrane
Molecular Function: bile acid transmembrane transporter activity; organic anion transmembrane transporter activity; sodium-independent organic anion transmembrane transporter activity
Biological Process: bile acid and bile salt transport; organic anion transport; sodium-independent organic anion transport
Reference #:  P46721 (UniProtKB)
Alt. Names/Synonyms: OATP; OATP-1; OATP-A; OATP1; OATP1A2; organic anion transporting polypeptide A; Organic anion-transporting polypeptide 1; SLC21A3; SLCO1A2; SO1A2; Sodium-independent organic anion transporter; solute carrier family 21 (organic anion transporter), member 3; Solute carrier family 21 member 3; Solute carrier organic anion transporter family member 1A2; solute carrier organic anion transporter family, member 1A2
Gene Symbols: SLCO1A2
Molecular weight: 74,145 Da
Basal Isoelectric point: 5.69  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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