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GLI2 Acts as a transcriptional activator. May play a role during embryogenesis. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the TRE-2S regulatory element that augments the Tax-dependent enhancer of human T-cell leukemia virus type 1. Implicated in the transduction of SHH signal. Interaction with ZIC. Belongs to the GLI C2H2-type zinc-finger protein family. 5 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 1 E2.3|1 52.17 cM
Cellular Component: axoneme; cell projection; cilium; cytoplasm; membrane; nuclear speck; nucleolus; nucleus
Molecular Function: chromatin binding; DNA binding; DNA binding transcription factor activity; metal ion binding; nucleic acid binding; protein binding; sequence-specific DNA binding; transcription factor binding; zinc ion binding
Biological Process: anatomical structure development; anatomical structure formation involved in morphogenesis; anterior/posterior pattern specification; axon guidance; branching morphogenesis of a tube; cell differentiation; cell proliferation; cerebellar cortex morphogenesis; chondrocyte differentiation; developmental growth; dorsal/ventral neural tube patterning; dorsal/ventral pattern formation; embryonic digit morphogenesis; embryonic gut development; epidermal cell differentiation; floor plate formation; heart development; hindbrain development; hindgut morphogenesis; in utero embryonic development; kidney development; lung development; mammary gland development; morphogenesis of an epithelium; multicellular organism development; negative regulation of apoptosis; negative regulation of chondrocyte differentiation; negative regulation of transcription from RNA polymerase II promoter; neural tube development; neuron development; notochord regression; odontogenesis of dentine-containing teeth; osteoblast development; osteoblast differentiation; pattern specification process; pituitary gland development; positive regulation of cell proliferation; positive regulation of DNA replication; positive regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; proximal/distal pattern formation; regulation of smoothened signaling pathway; regulation of transcription, DNA-templated; skeletal system development; smoothened signaling pathway; smoothened signaling pathway in regulation of granule cell precursor cell proliferation; smoothened signaling pathway involved in spinal cord motor neuron cell fate specification; smoothened signaling pathway involved in ventral spinal cord interneuron specification; spinal cord dorsal/ventral patterning; spinal cord motor neuron differentiation; spinal cord ventral commissure morphogenesis; transcription, DNA-dependent; tube development; ventral midline development; ventral spinal cord development
Reference #:  Q0VGT2 (UniProtKB)
Alt. Names/Synonyms: AW546128; GLI-Kruppel family member GLI2; Gli2; Tax helper protein
Gene Symbols: Gli2
Molecular weight: 165,031 Da
Basal Isoelectric point: 7.03  Predict pI for various phosphorylation states
CST Pathways:  Hedgehog Signaling
Select Structure to View Below


Protein Structure Not Found.

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