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PRKD1 a CAMK kinase of the PKD family. Cleavage by caspase-3 following DNA damage activates it and alters its subcellular localization. Sensitizes cells to apoptosis induced by genotoxic stress. Its cleavage is blocked in cells that over-express the anti-apoptotic Bcl-x(L) protein. Expression of a caspase-resistant mutant partially inhibits DNA damage-induced apoptosis. Its activation by TLR ligands is dependent on MyD88, IRAK4 and -1, but not TRAF6. Essential for MyD88-dependent proinflammatory immune responses. Activated by diacylglycerol and phorbol esters. Binds to the trans-Golgi network and regulates the fission of transport carriers specifically destined to the cell surface. Colocalizes with F-actin at peripheral F-actin-rich structures in membrane ruffles at the edge of lamellipodia in cervical carcinoma cells. Substrates reportedly include critical regulatory proteins including CREB, SSH1L, CTNNB1, HDACs 5 and 7, PKD1, HPK1, MARK2, PIP5K2A, PPP1R14A Note: This description may include information from UniProtKB.
Protein type: Autophagy; CAMK group; EC; Kinase, protein; Motility/polarity/chemotaxis; PKD family; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 14q12
Cellular Component: autophagosome membrane; cytosol; Golgi apparatus; integral component of plasma membrane; plasma membrane; trans-Golgi network
Molecular Function: ATP binding; identical protein binding; kinase activity; metal ion binding; protein binding; protein kinase C activity; protein serine/threonine kinase activity
Biological Process: angiogenesis; apoptosis; cell proliferation; cellular response to amino acid starvation; cellular response to hydroperoxide; cellular response to oxidative stress; Golgi organization and biogenesis; Golgi vesicle transport; inflammatory response; innate immune response; integrin-mediated signaling pathway; negative regulation of endocytosis; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; positive regulation of angiogenesis; positive regulation of autophagy; positive regulation of blood vessel endothelial cell migration; positive regulation of CREB transcription factor activity; positive regulation of endothelial cell chemotaxis; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of neuron projection development; positive regulation of NF-kappaB transcription factor activity; positive regulation of osteoblast differentiation; positive regulation of peptidyl-serine phosphorylation; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; protein autophosphorylation; protein kinase D signaling; Ras protein signal transduction; regulation of integrin-mediated signaling pathway; regulation of keratinocyte proliferation; regulation of protein stability; signal transduction; sphingolipid biosynthetic process; vascular endothelial growth factor receptor signaling pathway
Disease: Congenital Heart Defects And Ectodermal Dysplasia
Reference #:  Q15139 (UniProtKB)
Alt. Names/Synonyms: KPCD1; nPKC-D1; nPKC-mu; PKC-MU; PKCM; PKD; PKD1; PRKCM; PRKD1; Protein kinase C mu type; protein kinase C, mu; Protein kinase D; protein kinase D1; Serine/threonine-protein kinase D1
Gene Symbols: PRKD1
Molecular weight: 101,704 Da
Basal Isoelectric point: 6.16  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Inhibition of Apoptosis  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling  |  Protein Kinase C Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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