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NCOA4 Enhances the androgen receptor transcriptional activity in prostate cancer cells. Ligand-independent coactivator of the peroxisome proliferator-activated receptor (PPAR) gamma. Defects in NCOA4 are a cause of thyroid papillary carcinoma (TPC). TPC is a common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. A chromosomal aberration involving NCOA4 is found in thyroid papillary carcinomas. Inversion inv(10)(q11.2;q11.2) generates the RET/NCOA4 (PTC3) oncogene that has been found in sporadic and radiation-associated post-Chernobyl thyroid papillary carcinomas. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator; Oncoprotein
Chromosomal Location of Human Ortholog: 10q11.22
Cellular Component: mitochondrion; nucleus
Molecular Function: androgen receptor binding; transcription coactivator activity
Biological Process: androgen receptor signaling pathway; cellular iron ion homeostasis; male gonad development; positive regulation of transcription, DNA-templated; protein targeting to lysosome; transcription, DNA-dependent
Disease: Thyroid Carcinoma, Papillary
Reference #:  Q13772 (UniProtKB)
Alt. Names/Synonyms: 70 kDa androgen receptor coactivator; 70 kDa AR-activator; Androgen receptor coactivator 70 kDa protein; androgen receptor coactivator, 70-kD; Androgen receptor-associated protein of 70 kDa; ARA70; DKFZp762E1112; ELE1; NCoA-4; NCOA4; Nuclear receptor coactivator 4; papillary thyroid carcinoma 3; PTC3; ret fused; RET-activating gene ELE1; Ret-activating protein ELE1; RFG
Gene Symbols: NCOA4
Molecular weight: 69,726 Da
Basal Isoelectric point: 5.72  Predict pI for various phosphorylation states
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