May be involved in transcriptional regulation. Defects in ZNF469 are the cause of brittle cornea syndrome type 1 (BCS1). A disorder characterized by extreme corneal thinning resulting in corneal rupture after minor trauma, blue sclerae, keratoconus or keratoglobus, hyperelasticity of the skin, and hypermobility of the joints. It shares some features with, but is much less severe than, the ocular form of Ehlers-Danlos syndrome (EDS6). Belongs to the krueppel C2H2-type zinc-finger protein family. Note: This description may include information from UniProtKB.