Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

LYN a tyrosine kinase of the Src family that plays a role in B cell antigen-receptor signaling. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Oncoprotein; Protein kinase, TK; Protein kinase, tyrosine (non-receptor); Src family; TK group
Chromosomal Location of Human Ortholog: 4 A1|4 2.05 cM
Cellular Component: cell-cell adherens junction; cytoplasm; extrinsic to internal side of plasma membrane; Golgi apparatus; intracellular membrane-bound organelle; lipid raft; membrane; mitochondrial crista; mitochondrial intermembrane space; mitochondrial membrane; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density
Molecular Function: enzyme binding; erythropoietin receptor binding; gamma-tubulin binding; glycosphingolipid binding; integrin binding; non-membrane spanning protein tyrosine kinase activity; phosphoprotein binding; platelet-derived growth factor receptor binding; protein binding; protein complex binding; protein kinase activity; protein-tyrosine kinase activity; receptor binding; SH3 domain binding; ubiquitin protein ligase binding
Biological Process: B cell homeostasis; B cell receptor signaling pathway; central nervous system development; chemotaxis; cytokine secretion; erythrocyte differentiation; Fc receptor mediated inhibitory signaling pathway; Fc receptor mediated stimulatory signaling pathway; hemoglobin biosynthetic process; hemopoiesis; histamine secretion by mast cell; immune response-regulating cell surface receptor signaling pathway; lipopolysaccharide-mediated signaling pathway; negative regulation of B cell proliferation; negative regulation of cell proliferation; negative regulation of MAP kinase activity; negative regulation of myeloid leukocyte differentiation; negative regulation of protein amino acid phosphorylation; negative regulation of toll-like receptor 2 signaling pathway; negative regulation of toll-like receptor 4 signaling pathway; neurite development; peptidyl-tyrosine phosphorylation; platelet degranulation; positive regulation of B cell receptor signaling pathway; positive regulation of cell migration; positive regulation of cell motility; positive regulation of cell proliferation; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phosphoinositide 3-kinase activity; positive regulation of phosphorylation; positive regulation of tyrosine phosphorylation of STAT protein; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of B cell apoptosis; regulation of B cell receptor signaling pathway; regulation of cell adhesion mediated by integrin; regulation of cytokine production; regulation of cytokine secretion; regulation of erythrocyte differentiation; regulation of inflammatory response; regulation of mast cell activation; regulation of mast cell degranulation; regulation of release of sequestered calcium ion into cytosol; response to DNA damage stimulus; response to hormone stimulus; signal transduction; tolerance induction to self antigen; transmembrane receptor protein tyrosine kinase signaling pathway
Reference #:  P25911 (UniProtKB)
Alt. Names/Synonyms: AA407514; Hck-2; Lyn; OTTMUSP00000004775; Tyrosine-protein kinase Lyn; Yamaguchi sarcoma viral (v-yes-1) oncogene homolog
Gene Symbols: Lyn
Molecular weight: 58,812 Da
Basal Isoelectric point: 6.74  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  GPCR Signaling to MAPKs  |  PI3K/Akt Signaling  |  Tyrosine Kinases & Substrates
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

Substrate Sequence Logo
Sequence Logo

STRING  |  Reactome  |  BioGPS  |  Scansite  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene