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AMPKG2 AMP/ATP-binding subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit (PRKAA1 or PRKAA2) both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits. ADP also stimulates phosphorylation, without stimulating already phosphorylated catalytic subunit. ATP promotes dephosphorylation of catalytic subunit, rendering the AMPK enzyme inactive. AMPK is a heterotrimer of an alpha catalytic subunit (PRKAA1 or PRKAA2), a beta (PRKAB1 or PRKAB2) and a gamma non- catalytic subunits (PRKAG1, PRKAG2 or PRKAG3). Interacts with FNIP1 and FNIP2. Isoform B is ubiquitously expressed except in liver and thymus. The highest level is detected in heart with abundant expression in placenta and testis. Belongs to the 5'-AMP-activated protein kinase gamma subunit family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: 7q36.1
Cellular Component: cytosol; extracellular space; nucleoplasm; nucleotide-activated protein kinase complex
Molecular Function: ADP binding; AMP binding; AMP-activated protein kinase activity; ATP binding; cAMP-dependent protein kinase inhibitor activity; cAMP-dependent protein kinase regulator activity; phosphorylase kinase regulator activity; protein kinase activator activity; protein kinase binding
Biological Process: activation of protein kinase activity; ATP biosynthetic process; carnitine shuttle; cell cycle arrest; fatty acid biosynthetic process; glycogen metabolic process; macroautophagy; negative regulation of protein kinase activity; positive regulation of protein kinase activity; protein amino acid phosphorylation; regulation of fatty acid biosynthetic process; regulation of fatty acid metabolic process; regulation of fatty acid oxidation; regulation of glucose import; regulation of glycolysis; regulation of macroautophagy; sterol biosynthetic process
Disease: Cardiomyopathy, Familial Hypertrophic, 6; Glycogen Storage Disease Of Heart, Lethal Congenital; Wolff-parkinson-white Syndrome
Reference #:  Q9UGJ0 (UniProtKB)
Alt. Names/Synonyms: 5'-AMP-activated protein kinase subunit gamma-2; AAKG; AAKG2; AMPK gamma2; AMPK subunit gamma-2; CMH6; H91620p; PRKAG2; protein kinase, AMP-activated, gamma 2 non-catalytic subunit; WPWS
Gene Symbols: PRKAG2
Molecular weight: 63,066 Da
Basal Isoelectric point: 9.37  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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