Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

HPK1 a protein kinase of the STE20 family. Expressed primarily in hematopoietic organs, including bone marrow, spleen and thymus. Also expressed at very low levels in lung, kidney, mammary glands and small intestine. May play a role in hematopoietic lineage decisions and growth regulation. Positively regulated by PGE2 and a negative regulator of PGE2-induced FOS gene transcription. Note: This description may include information from UniProtKB.
Protein type: EC; KHS subfamily; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE20 family
Chromosomal Location of Human Ortholog: 7|7 B1
Cellular Component: cytoplasm; membrane
Molecular Function: ATP binding; kinase activity; MAP kinase kinase kinase kinase activity; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process: cell proliferation; peptidyl-serine phosphorylation; phosphorylation; protein amino acid phosphorylation; protein autophosphorylation; regulation of apoptosis; regulation of mitotic cell cycle; response to stress; stress-activated protein kinase signaling pathway
Reference #:  P70218 (UniProtKB)
Alt. Names/Synonyms: Hematopoietic progenitor kinase; hematopoietic progenitor kinase 1; HPK; Hpk1; M4K1; Map4k1; MAPK/ERK kinase kinase kinase 1; MEK kinase kinase 1; MEKKK 1; mHPK1; mitogen activated protein kinase kinase kinase kinase 1; Mitogen-activated protein kinase kinase kinase kinase 1
Gene Symbols: Map4k1
Molecular weight: 91,535 Da
Basal Isoelectric point: 8.11  Predict pI for various phosphorylation states
CST Pathways:  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.
Download PyMol Script
Download ChimeraX Script

STRING  |  BioGPS  |  Scansite  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene