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APOA5 Minor apolipoprotein mainly associated with HDL and to a lesser extent with VLDL. May also be associated with chylomicrons. Important determinant of plasma triglyceride (TG) levels by both being a potent stimulator of apo-CII lipoprotein lipase (LPL) TG hydrolysis and a inhibitor of the hepatic VLDL-TG production rate (without affecting the VLDL-apoB production rate). Activates poorly lecithin:cholesterol acyltransferase (LCAT) and does not enhance efflux of cholesterol from macrophages. Interacts with GPIHBP1. Up-regulated by PPARA agonists, which are used clinically to lower serum TG (such as fibrates). Liver and plasma. Belongs to the apolipoprotein A1/A4/E family. Note: This description may include information from UniProtKB.
Protein type: Lipid-binding; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: chylomicron; endoplasmic reticulum lumen; extracellular region; extracellular space
Molecular Function: cholesterol binding; cholesterol transporter activity; enzyme activator activity; enzyme binding; heparin binding; lipid binding; low-density lipoprotein receptor binding; phosphatidylcholine binding; phospholipid binding
Biological Process: acylglycerol homeostasis; cellular protein metabolic process; cholesterol biosynthetic process; cholesterol efflux; cholesterol homeostasis; lipid transport; lipoprotein metabolic process; neuron projection regeneration; phosphatidylcholine metabolic process; phospholipid efflux; positive regulation of fatty acid biosynthetic process; positive regulation of lipid catabolic process; positive regulation of lipoprotein lipase activity; positive regulation of receptor-mediated endocytosis; post-translational protein modification; regulation of intestinal cholesterol absorption; regulation of lipid metabolic process; reverse cholesterol transport; tissue regeneration; triacylglycerol metabolic process; triglyceride catabolic process
Disease: Hyperlipoproteinemia, Type V; Hypertriglyceridemia, Familial
Reference #:  Q6Q788 (UniProtKB)
Alt. Names/Synonyms: Apo-AV; ApoA-V; APOA5; APOAV; Apolipoprotein A-V; Apolipoprotein A5; FLJ97995; MGC126836; MGC126838; RAP3; Regeneration-associated protein 3
Gene Symbols: APOA5
Molecular weight: 41,213 Da
Basal Isoelectric point: 5.98  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

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