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APOA1 Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1. Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease. Belongs to the apolipoprotein A1/A4/E family. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; Endoplasmic reticulum; Lipid-binding; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide; Vesicle
Chromosomal Location of Human Ortholog: 11q23.3
Cellular Component: cell surface; chylomicron; cytoplasmic vesicle; cytosol; early endosome; endocytic vesicle; endoplasmic reticulum lumen; extracellular matrix; extracellular region; extracellular space; nucleus; plasma membrane
Molecular Function: amyloid-beta binding; apolipoprotein A-I receptor binding; apolipoprotein receptor binding; chemorepellent activity; cholesterol binding; cholesterol transporter activity; enzyme binding; heat shock protein binding; high-density lipoprotein particle binding; identical protein binding; lipase inhibitor activity; phosphatidylcholine binding; phospholipid binding; phospholipid transporter activity; protein binding
Biological Process: adrenal gland development; axon regeneration in the peripheral nervous system; blood vessel endothelial cell migration; cellular protein metabolic process; cholesterol biosynthetic process; cholesterol efflux; cholesterol homeostasis; cholesterol metabolic process; cholesterol transport; endothelial cell proliferation; G-protein coupled receptor signaling pathway; glucocorticoid metabolic process; integrin-mediated signaling pathway; lipid storage; lipoprotein biosynthetic process; lipoprotein metabolic process; negative chemotaxis; negative regulation of cytokine secretion involved in immune response; negative regulation of heterotypic cell-cell adhesion; negative regulation of inflammatory response; negative regulation of interleukin-1 beta secretion; negative regulation of lipase activity; neuron projection regeneration; organ regeneration; peptidyl-methionine modification; phosphatidylcholine biosynthetic process; phospholipid efflux; phospholipid homeostasis; platelet degranulation; positive regulation of fatty acid biosynthetic process; positive regulation of hydrolase activity; positive regulation of lipoprotein lipase activity; positive regulation of Rho protein signal transduction; positive regulation of stress fiber formation; post-translational protein modification; protein oxidation; protein stabilization; receptor-mediated endocytosis; regulation of Cdc42 protein signal transduction; regulation of intestinal cholesterol absorption; regulation of lipid metabolic process; regulation of protein amino acid phosphorylation; response to drug; response to estrogen; response to nutrient; retinoid metabolic process; reverse cholesterol transport; transforming growth factor beta receptor signaling pathway; transmembrane transport; triglyceride catabolic process; vitamin transport
Disease: Amyloidosis, Familial Visceral; Hypoalphalipoproteinemia, Primary
Reference #:  P02647 (UniProtKB)
Alt. Names/Synonyms: Apo-AI; ApoA-I; APOA1; Apolipoprotein A-I; Apolipoprotein A-I(1-242); Apolipoprotein A1; MGC117399
Gene Symbols: APOA1
Molecular weight: 30,778 Da
Basal Isoelectric point: 5.56  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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