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NCCT Key mediator of sodium and chloride reabsorption in this nephron segment, accounting for a significant fraction of renal sodium reabsorption. Interacts with KLHL3. Predominant in kidney. Activated by WNK3. Belongs to the SLC12A transporter family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 16q13
Cellular Component: apical plasma membrane; cytosol; integral component of plasma membrane; membrane; plasma membrane
Molecular Function: protein binding; sodium:chloride symporter activity; transporter activity
Biological Process: ion transport; sodium ion transport; transport
Disease: Gitelman Syndrome
Reference #:  P55017 (UniProtKB)
Alt. Names/Synonyms: FLJ96318; Na-Cl symporter; NaCl electroneutral thiazide-sensitive cotransporter; NCCT; S12A3; SLC12A3; solute carrier family 12 (sodium/chloride transporters), member 3; Solute carrier family 12 member 3; thiazide-sensitive Na-Cl cotransporter; Thiazide-sensitive sodium-chloride cotransporter; TSC
Gene Symbols: SLC12A3
Molecular weight: 113,139 Da
Basal Isoelectric point: 8.1  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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