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P2X1 Ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle. Seems to be linked to apoptosis, by increasing the intracellular concentration of calcium in the presence of ATP, leading to programmed cell death. Belongs to the P2X receptor family. Note: This description may include information from UniProtKB.
Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 17p13.2
Cellular Component: integral to nuclear inner membrane; plasma membrane; secretory granule membrane
Molecular Function: ATP-gated cation channel activity; cation channel activity; purinergic nucleotide receptor activity
Biological Process: blood coagulation; ion transport; neutrophil degranulation; signal transduction; transport
Disease: Bleeding Disorder, Platelet-type, 8
Reference #:  P51575 (UniProtKB)
Alt. Names/Synonyms: P2RX1; P2X purinoceptor 1; P2X receptor, subunit 1; P2X1; P2X1 receptor; purinergic receptor P2X, ligand-gated ion channel, 1
Gene Symbols: P2RX1
Molecular weight: 44,980 Da
Basal Isoelectric point: 8.75  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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