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AT2 Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation. Defects in AGTR2 are the cause of mental retardation X- linked type 88 (MRX88). Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Belongs to the G-protein coupled receptor 1 family. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of Human Ortholog: Xq23
Cellular Component: extracellular region; integral component of plasma membrane; perinuclear region of cytoplasm; plasma membrane
Molecular Function: angiotensin type II receptor activity; peptide hormone binding; protein binding; receptor antagonist activity; transcription factor binding
Biological Process: angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure; blood vessel remodeling; brain development; brain renin-angiotensin system; cell surface receptor signaling pathway; cellular sodium ion homeostasis; cerebellar cortex development; dopamine biosynthetic process; G-protein coupled receptor signaling pathway; G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; inflammatory response; negative regulation of blood vessel endothelial cell migration; negative regulation of cell growth; negative regulation of fibroblast proliferation; negative regulation of heart rate; negative regulation of icosanoid secretion; negative regulation of neurotrophin TRK receptor signaling pathway; nitric oxide mediated signal transduction; positive regulation of cell proliferation; positive regulation of cytokine secretion; positive regulation of nitric oxide biosynthetic process; positive regulation of nitric-oxide synthase activity; positive regulation of phosphoprotein phosphatase activity; positive regulation of transcription, DNA-templated; regulation of blood pressure; regulation of systemic arterial blood pressure by circulatory renin-angiotensin; regulation of transcription factor import into nucleus; renin-angiotensin regulation of aldosterone production; vasodilation
Reference #:  P50052 (UniProtKB)
Alt. Names/Synonyms: AGTR2; angiotensin II receptor, type 2; Angiotensin II type-2 receptor; AT2; ATGR2; MRX88; Type-2 angiotensin II receptor
Gene Symbols: AGTR2
Molecular weight: 41,184 Da
Basal Isoelectric point: 9.31  Predict pI for various phosphorylation states
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