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Protein Page:

SRCAP Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. Defects in SRCAP are the cause of Floating-Harbor syndrome (FLHS). A rare genetic disorder characterized by proportionate short stature, delayed bone age, delayed speech development, and typical facial features. The face is triangular with deep-set eyes, long eyelashes, bulbous nose, wide columella, short philtrum, and thin lips. Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Acetyltransferase; DNA-binding; EC 3.6.1.-; EC 3.6.4.-; Helicase; Transcription, coactivator/corepressor
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component: Golgi apparatus; nuclear body; nucleoplasm; nucleus; perinuclear region of cytoplasm; protein complex
Molecular Function: ATP binding; DNA binding; helicase activity; histone acetyltransferase activity; protein binding; transcription coactivator activity
Biological Process: histone acetylation; regulation of transcription from RNA polymerase II promoter; transcription, DNA-dependent; viral process
Disease: Floating-harbor Syndrome
Reference #:  Q6ZRS2 (UniProtKB)
Alt. Names/Synonyms: domino homolog 1; Domino homolog 2; DOMO1; EAF1; FLJ44499; Helicase SRCAP; KIAA0309; Snf2-related CBP activator; Snf2-related CBP activator protein; Snf2-related CREBBP activator protein; SRCAP; Swi2/Snf2-related ATPase homolog, domino homolog 1; SWR1
Gene Symbols: SRCAP
Molecular weight: 343,555 Da
Basal Isoelectric point: 5.69  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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