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POLR3E DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: EC; Transcription initiation complex; Transferase
Chromosomal Location of Human Ortholog: 16p12.2
Cellular Component: cytosol; DNA-directed RNA polymerase III complex; nucleoplasm; nucleus
Biological Process: positive regulation of interferon type I production
Reference #:  Q9NVU0 (UniProtKB)
Alt. Names/Synonyms: DNA-directed RNA polymerase III 80 kDa polypeptide; DNA-directed RNA polymerase III subunit RPC5; KIAA1452; POLR3E; polymerase (RNA) III (DNA directed) polypeptide E (80kD); RNA polymerase III 80 kDa subunit RPC5; RNA polymerase III subunit C5; RPC5; SIN
Gene Symbols: POLR3E
Molecular weight: 79,898 Da
Basal Isoelectric point: 6.05  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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