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ERK3 a protein kinase of the MAPK family. Plays a critical role in the regulation of cell growth and differentiation. Localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. Note: This description may include information from UniProtKB.
Protein type: CMGC group; EC; ERK subfamily; Kinase, protein; MAPK family; MAPK/ERK subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 9 D|9 42.3 cM
Cellular Component: cytoplasm; cytosol; nucleus; protein complex
Molecular Function: MAP kinase activity; protein binding; protein heterodimerization activity; protein kinase activity; protein kinase binding
Biological Process: protein amino acid phosphorylation; regulation of gene expression
Reference #:  Q61532 (UniProtKB)
Alt. Names/Synonyms: 2610021I23Rik; D130053K17Rik; ERK-3; Erk-3 related; Erk3; Extracellular signal-regulated kinase 3; MAP kinase 6; MAPK 6; Mapk4; Mapk6; Mapk63; mitogen activated protein kinase 4; mitogen activated protein kinase 6; Mitogen-activated protein kinase 6; MK06; Prkm4; Prkm6; protein kinase, mitogen activated kinase 4
Gene Symbols: Mapk6
Molecular weight: 82,199 Da
Basal Isoelectric point: 5.05  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  IL6 Signaling  |  Microtubule Dynamics  |  mTOR Signaling  |  Translation: eIF4E and p70S6K
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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