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ATP5F1 Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Belongs to the eukaryotic ATPase B chain family. Note: This description may include information from UniProtKB.
Protein type: EC; Energy Metabolism - oxidative phosphorylation; Hydrolase; Mitochondrial
Chromosomal Location of Human Ortholog: 1p13.2
Cellular Component: membrane; mitochondrial inner membrane; mitochondrial proton-transporting ATP synthase complex; mitochondrion; nucleoplasm; nucleus
Molecular Function: ATPase activity; hydrogen ion transporting ATP synthase activity, rotational mechanism; protein binding; transmembrane transporter activity
Biological Process: ATP biosynthetic process; ATP synthesis coupled proton transport; cristae formation; mitochondrial ATP synthesis coupled proton transport; substantia nigra development
Reference #:  P24539 (UniProtKB)
Alt. Names/Synonyms: AT5F1; ATP synthase B chain, mitochondrial; ATP synthase subunit b, mitochondrial; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit b, isoform 1; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit B1; ATP5F1; ATPase subunit b; cell proliferation-inducing protein 47; H+-ATP synthase subunit b; MGC24431; PIG47
Gene Symbols: ATP5F1
Molecular weight: 28,909 Da
Basal Isoelectric point: 9.37  Predict pI for various phosphorylation states
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Protein Structure Not Found.
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