Javascript is not enabled on this browser. This site will not work properly without Javascript.
PhosphoSitePlus Homepage Cell Signaling Technology
Home | Login
About PhosphoSiteUsing PhosphoSiteprivacy & cookiesCuration ProcessContact
logos LINCs Logo Mt Sinai Logo NIH Logo NCI Logo
Search / Browse Functions
Protein Page:

Oct8 Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development. Is implicated in an enhancer activity at the embryonic met- mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3'). Belongs to the POU transcription factor family. Class- 3 subfamily. Note: This description may include information from UniProtKB.
Protein type: DNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 2q12.1
Cellular Component: nucleus
Molecular Function: DNA binding transcription factor activity; sequence-specific DNA binding
Biological Process: central nervous system development; cerebral cortex radially oriented cell migration; chemical homeostasis; excretion; forebrain ventricular zone progenitor cell division; negative regulation of apoptosis; negative regulation of transcription, DNA-dependent; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; transcription, DNA-dependent
Reference #:  P20264 (UniProtKB)
Alt. Names/Synonyms: Brain-1; Brain-specific homeobox/POU domain protein 1; Brn-1; BRN1; Oct-8; Octamer-binding protein 8; Octamer-binding transcription factor 8; OTF-8; OTF8; POU domain, class 3, transcription factor 3
Gene Symbols: POU3F3
Molecular weight: 50,327 Da
Basal Isoelectric point: 7.51  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Scansite  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein